In Alphabet Order
Neural development and aging
Nervous system procedurally acquires the abilities to sense the world and control adaptive motor output during neural development. The processes and mechanisms of how progenitor cells form a nervous system during embryogenesis, and how the initially formed neural circuits are shaped by experience during early postnatal life, as well as renewal, regeneration and aging in adults remain blurry. Studies on neural development will disclose the cellular and molecular mechanisms of complex nervous systems emerge during embryogenesis and aging throughout life.
Embryogenesis and stem cells
Important events occur during embryogenesis. Monkeys have served as the most valuable models for understanding gene expression regulation and DNA methylation dynamics during fertilization, cleavage, gastulation, nervous system formation and organogenesis initiation in early embryogenesis in human. The progresses in stem cell research lead deep insights of the processes of life forms begin, develop, mature, injure, regeneration and ageing.
Disease model and therapy
Nonhuman primates have been considered as the best preclinical models that closely reflect human physiological characteristics and behaviors. Major breakthroughs in stem cell and gene editing technology have displayed vast clinical therapeutic potentials and promise great prospects for treatment of degenerative, chronic and/or fatal diseases and injuries in human clinical trial. The employment of new therapeutic methods and potential applications of nonhuman primate disease models in preclinical research involve safety and efficacy evaluation.
The development of frontier technologies greatly aids the advanced research of development and stem cells and provides prospect of revealing of nature of life. New gene editing methods permit rapid and efficient genomic modifications, and are increasingly used in the laboratory and are potential tools for gene therapy in humans. The breakthrough of primate somatic cell nuclear transfer will contribute great potential application for genetic editing and diseases mechanism study. Meanwhile, the new methods of deep sequencing on genome-wide scale sequencing of single cell provide detailed insights into individual cells and make it possible to study embryogenesis and disease mechanisms.